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Performance Medicine Institute // Research
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At the Performance Medicine Institute, our commitment to advancing science is not just a slogan, it’s part of our daily clinical practice. Our providers have authored nearly 100 peer-reviewed research studies published in respected scientific journals. This places us among the most highly published clinical teams in sports medicine and musculoskeletal care in the Southwest.

Why does this matter to you as a patient? It means that the care you receive is shaped by the latest scientific evidence, much of which we have helped produce. Our research spans topics such as injury prevention, joint and muscle rehabilitation, hormonal health, performance recovery, and regenerative therapies — areas where we’re not only applying best practices, but actively defining them.

Because we work at the intersection of academic medicine and real-world clinical outcomes, we are often early adopters of emerging treatments supported by strong evidence. Whether it’s using advanced diagnostics, innovative therapies like platelet-rich plasma (PRP), or precision medicine tools based on your genetic profile, our approach is grounded in data and driven by results.

By choosing our team, you’re not just getting routine care, you’re gaining access to a medical practice that sets the standard for others to follow.

Our providers have published nearly 100 research studies in scientific journals, making us among the most highly published sports medicine and musculoskeletal clinical teams in Arizona. We think research is an important part of improving medical practice, and by choosing us for your care, you are getting the latest in evidenced-based medical treatments that many other clinics don't offer.

  • Mendias C, Awan T. Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance. Preprint Link: https://doi.org/10.20944/preprints202512.1011.v1
  • Mendias C, Awan T. Rapid and Sustained Resolution of Scrotal Content Pain Through Multimodal Integrative Neuromuscular Interventions. medRxiv 2025 10.20.25338413. Preprint Link: https://www.medrxiv.org/content/10.1101/2025.10.20.25338413v2
  • Li H, Mendias C, Awad H, Looney R, Roseo S, Ciufo D, Cao C. TriNetX Analytics Network analyses of the USA population reveals a bidirectional association between hypertension and tendinopathy related to β-adrenergic signaling and L-type calcium channel function. ASBMR Annual Meeting 2024. Abstract Link: https://asbmr.confex.com/asbmr/2024/meetingapp.cgi/Paper/3312
  • Ciufo D, Cao C, Mendias C, Li H. Clinical Association of Achilles Tendinopathy and Hypertension Mediated by CaV1.2 Voltage-gated Ca2+ Channel. Foot Ankle Orthop. 2023 Dec 23;8(4):2473011423S00084. PubMed Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC10748684/
  • Li H, Korcari A, Ciufo D, Mendias CL, Rodeo SA, Buckley MR, Loiselle AE, Pitt GS, Cao C. Increased Ca2+signaling through CaV 1.2 induces tendon hypertrophy with increased collagen fibrillogenesis and biomechanical properties. FASEB J. 2023 Jul;37(7):e23007. PMID: 37261735. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/37261735/
  • Murray IR, Chahla J, Wordie SJ, Shapiro SA, Piuzzi NS, Frank RM, Halbrecht J, Okada K, Nakamura N, Mandelbaum B, Dragoo JL, Biologics Association, Borg-Stein J, Anz A, Gobbi A, Gomoll AH, Cole BJ, Lattermann C, Chu C, Grande DA, Saris DBF, Flanigan D, Kon E, Muschler GF, Malanga GA, Dummer G, Farr J, Tokish JM, Spindler KP, Horsch K, Zaslav K, McIntyre LF, Sgaglione NA, Sherman SL, Rodeo S, Awan TM, Vangsness CT. Regulatory and Ethical Aspects of Orthobiologic Therapies. Orthop J Sports Med. 2022 Nov;10(11):23259671221101626. PMID: 36479465. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/36479465/
  • Patel SH, Mendias CL, Carroll CC. Descriptive transcriptome analysis of tendon derived fibroblasts following in-vitro exposure to advanced glycation end products. PLoS One. 2022 Jul;17(7):e0271770. PMID: 35881579. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/35881579/
  • Shapiro SA, Finnoff JT, Awan TM, Borg-Stein JP, Harmon KG, Herman DC, Malanga G, Master Z, Mautner K. Highlights from the American Medical Society for Sports Medicine position statement on responsible use of regenerative medicine and orthobiologics in sports medicine. Br J Sports Med. 2022 Feb;56(3):121-122. PMID: 34719428. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/34719428/
  • Yu JS, Dare DM, Edon D, Sinatro AL, Sarver DC, Rodeo S, Dines JS, Mendias CL. Shoulder Lesions Do Not Increase Inflammatory Biomarkers in Patients Undergoing Surgery for Glenohumeral Instability: An Exploratory Study. Transl Sports Med. 2022 Feb 27:2022:4220356. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/38655158/
  • Finnoff JT, Awan TM, Borg-Stein J, Harmon KG, Herman DC, Malanga GA, Master Z, Mautner KR, Shapiro SA. American Medical Society for Sports Medicine Position Statement: Principles for the Responsible Use of Regenerative Medicine in Sports Medicine. Clin J Sport Med. 2021 Nov;31(6):530-541. PMID: 34704973. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/34704973/
  • LeBrun DG, Konnaris MA, Ghahramani GC, Premkumar A, DeFrancesco CJ, Gruskay JA, Dvorzhinskiy A, Sandhu MS, Goldwyn EM, Mendias CL, Ricci WM. Increased Comorbidity Burden Among Hip Fracture Patients During the COVID-19 Pandemic in New York City. Geriatr Orthop Surg Rehabil. 2021 Sep;12:21514593211040611. PMID: 34522445. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/34522445/
  • Olesen JL, Hansen M, Turtumoygard IF, Hoffner R, Schjerling P, Christensen J, Mendias CL, Magnusson PS, Kjaer M. No Treatment Benefits of Local Administration of Insulin-like Growth Factor-1 in Addition to Heavy Slow Resistance Training in Tendinopathic Human Patellar Tendons: A Randomized, Double-Blind, Placebo-Controlled Trial With 1-Year Follow-up. Am J Sports Med. 2021 Jul;49(9):2361-2370. PMID: 34138667. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/34138667/
  • Jeffery NS, Sarver DC, Mendias CL. Ontogenetic and in silico models of spatial-packing in the hypermuscular mouse skull. J Anat. 2021 Jun;238(6):1284-1295. PMID: 33438210. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/33438210/
  • Van Pelt DW, Kharaz YA, Sarver DC, Eckhardt LR, Dzierzawski JT, Disser NP, Piacentini AN, Comerford E, McDonagh B, Mendias CL. Multiomics analysis of the mdx/mTR mouse model of Duchenne muscular dystrophy. Connect Tissue Res. 2021 Jan;62(1):24-39. PMID: 32664808. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/32664808/
  • De Micheli AJ, Swanson JB, Disser NP, Martinez LM, Walker NR, Oliver DJ, Cosgrove BD, Mendias CL. Single-cell transcriptomic analysis identifies extensive heterogeneity in the cellular composition of mouse Achilles tendons. Am J Physiol Cell Physiol. 2020 Nov;319(5):C885-C894. PMID: 32877217. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/32877217/
  • Dehdashtian A, Bratley JV, Svientek SR, Kung TA, Awan TM, Cederna PS, Kemp SWP. Autologous fat grafting for nerve regeneration and neuropathic pain: current state from bench-to-bedside. Regen Med. 2020 Oct;15(10):2209-2228. PMID: 33264053. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/33264053/
  • Gruskay JA, Dvorzhinskiy A, Konnaris MA, LeBrun DG, Ghahramani GC, Premkumar A, DeFrancesco CJ, Mendias CL, Ricci WM. Universal Testing for COVID-19 in Essential Orthopaedic Surgery Reveals a High Percentage of Asymptomatic Infections. J Bone Joint Surg Am. 2020 Aug;102(16):1379-1388. PMID: 32516279. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/32516279/
  • LeBrun DG, Konnaris MA, Ghahramani GC, Premkumar A, DeFrancesco CJ, Gruskay JA, Dvorzhinskiy A, Sandhu MS, Goldwyn EM, Mendias CL, Ricci WM. Hip Fracture Outcomes During the COVID-19 Pandemic: Early Results From New York. J Orthop Trauma. 2020 Aug;34(8):403-410. PMID: 32482977. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/32482977/
  • Disser NP, De Micheli AJ, Schonk MM, Konnaris MA, Piacentini AN, Edon DL, Toresdahl BG, Rodeo SA, Casey EK, Mendias CL. Musculoskeletal Consequences of COVID-19. J Bone Joint Surg Am. 2020 Jul;102(14):1197-1204. PMID: 32675661. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/32675661/
  • Gumucio JP, Schonk MM, Kharaz YA, Comerford E, Mendias CL. Scleraxis is required for the growth of adult tendons in response to mechanical loading. JCI Insight. 2020 Jul;5(13):e138295. PMID: 32463804. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/32463804/
  • Mendias CL, Enselman ERS, Olszewski AM, Gumucio JP, Edon DL, Konnaris MA, Carpenter JE, Awan TM, Jacobson JA, Gagnier JJ, Barkan AL, Bedi A. The Use of Recombinant Human Growth Hormone to Protect Against Muscle Weakness in Patients Undergoing Anterior Cruciate Ligament Reconstruction: A Pilot, Randomized Placebo-Controlled Trial. Am J Sports Med. 2020 Jul;48(8):1916-1928. PMID: 32452208. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/32452208/
  • Talarek JR, Piacentini AN, Konja AC, Wada S, Swanson JB, Nussenzweig SC, Dines JS, Rodeo SA, Mendias CL. The MRL/MpJ Mouse Strain Is Not Protected From Muscle Atrophy and Weakness After Rotator Cuff Tear. J Orthop Res. 2020 Apr;38(4):811-822. PMID: 31696955. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/31696955/
  • Disser NP, Ghahramani GC, Swanson JB, Wada S, Chao ML, Rodeo SA, Oliver DJ, Mendias CL. Widespread diversity in the transcriptomes of functionally divergent limb tendons. J Physiol. 2020 Apr;598(8):1537-1550. PMID: 32083717. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/32083717/
  • Curran MT, Bedi A, Mendias CL, Wojtys EM, Kujawa MV, Palmieri-Smith RM. Blood Flow Restriction Training Applied With High-Intensity Exercise Does Not Improve Quadriceps Muscle Function After Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial. Am J Sports Med. 2020 Mar;48(4):825-837. PMID: 32167837. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/32167837/
  • Noah AC, Li TM, Martinez LM, Wada S, Swanson JB, Disser NP, Sugg KB, Rodeo SA, Lu TT, Mendias CL. Adaptive and innate immune cell responses in tendons and lymph nodes after tendon injury and repair. J Appl Physiol (1985). 2020 Mar;128(3):473-482. PMID: 31944888. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/31944888/
  • Mendias CL, Bedi A. RE: Talks BJ, Fernquest S, Palmer A, et al. 2019. No Evidence of Systemic Inflammation in Symptomatic Patients With Femoroacetabular Impingement. J Orthop Res. 2019 Dec;37(12):2621-2622. PMID: 31343771. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/31343771/
  • Disser NP, Sugg KB, Talarek JR, Sarver DC, Rourke BJ, Mendias CL. Insulin-like growth factor 1 signaling in tenocytes is required for adult tendon growth. FASEB J. 2019 Nov;33(11):12680-12695. PMID: 31536390. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/31536390/
  • Sarver DC, Sugg KB, Talarek JR, Swanson JB, Oliver DJ, Hinken AC, Kramer HF, Mendias CL. Prostaglandin D2 signaling is not involved in the recovery of rat hind limb tendons from injury. Physiol Rep. 2019 Nov;7(22):e14289. PMID: 31782241. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/31782241/
  • Gok E, Alghanem F, Lim E, Sarver D, Eckhardt L, Christensen S, Hoenerhoff M, Mendias C, Ozer K. Single Muscle Fibre Contractility Testing in Rats to Quantify Ischaemic Muscle Damage During Reperfusion Injury. Eur J Vasc Endovasc Surg. 2019 Aug;58(2):249-256. PMID: 31202581. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/31202581/
  • Gumucio JP, Qasawa AH, Ferrara PJ, Malik AN, Funai K, McDonagh B, Mendias CL. Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis. FASEB J. 2019 Jul;33(7):7863-7881. PMID: 30939247. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/30939247/
  • Pataky MW, Yu CS, Nie Y, Arias EB, Singh M, Mendias CL, Ploutz-Snyder RJ, Cartee GD. Skeletal muscle fiber type-selective effects of acute exercise on insulin-stimulated glucose uptake in insulin-resistant, high-fat-fed rats. Am J Physiol Endocrinol Metab. 2019 May;316(5):E695-E706. PMID: 30753114. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/30753114/
  • Patel K, Bakshi N, Freehill MT, Awan TM. Whole-Body Cryotherapy in Sports Medicine. Curr Sports Med Rep. 2019 Apr;18(4):136-140. PMID: 30969239. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/30969239/
  • Oliver K, Bayes M, Awan T. Two-fold Increase in the Number of Total Nucleated Cells in the Bone Marrow Concentrate Obtained From the Bone Marrow Aspirate May Not Be Ideal: Response. Orthop J Sports Med. 2019 Mar;7(3):2325967119835187. PMID: 30969283. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/30969283/
  • Schubert MF, Noah AC, Bedi A, Gumucio JP, Mendias CL. Reduced Myogenic and Increased Adipogenic Differentiation Capacity of Rotator Cuff Muscle Stem Cells. J Bone Joint Surg Am. 2019 Feb;101(3):228-238. PMID: 30730482. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/30730482/
  • Ahtiainen JP, Lensu S, Ruotsalainen I, Schumann M, Ihalainen JK, Fachada V, Mendias CL, Brook MS, Smith K, Atherton PJ, Koch LG, Britton SL, Kainulainen H. Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training. Exp Physiol. 2018 Nov;103(11):1513-1523. PMID: 30184287. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/30184287/
  • Henning PT, Yang L, Awan T, Lueders D, Pourcho AM. Minimally Invasive Ultrasound-Guided Carpal Tunnel Release: Preliminary Clinical Results. J Ultrasound Med. 2018 Nov;37(11):2699-2706. PMID: 29608024. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/29608024/
  • Syverud BC, Gumucio JP, Rodriguez BL, Wroblewski OM, Florida SE, Mendias CL, Larkin LM. A Transgenic tdTomato Rat for Cell Migration and Tissue Engineering Applications. Tissue Eng Part C Methods. 2018 May;24(5):263-271. PMID: 29490563. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/29490563/
  • Sugg KB, Markworth JF, Disser NP, Rizzi AM, Talarek JR, Sarver DC, Brooks SV, Mendias CL. Postnatal tendon growth and remodeling require platelet-derived growth factor receptor signaling. Am J Physiol Cell Physiol. 2018 Apr;314(4):C389-C403. PMID: 29341790. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/29341790/
  • Gumucio JP, Sugg KB, Enselman ERS, Konja AC, Eckhardt LR, Bedi A, Mendias CL. Anterior cruciate ligament tear induces a sustained loss of muscle fiber force production. Muscle Nerve. 2018 Jan;10.1002/mus.26075. PMID: 29346717. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/29346717/
  • Mead MP, Gumucio JP, Awan TM, Mendias CL, Sugg KB. Pathogenesis and Management of Tendinopathies in Sports Medicine. Transl Sports Med. 2018 Jan;1(1):5-13. PMID: 31131372. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/31131372/
  • Novakova SS, Mahalingam VD, Florida SE, Mendias CL, Allen A, Arruda EM, Bedi A, Larkin LM. Tissue-engineered tendon constructs for rotator cuff repair in sheep. J Orthop Res. 2018 Jan;36(1):289-299. PMID: 28657154. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/28657154/
  • Wurtzel CN, Gumucio JP, Grekin JA, Khouri RK Jr, Russell AJ, Bedi A, Mendias CL. Pharmacological inhibition of myostatin protects against skeletal muscle atrophy and weakness after anterior cruciate ligament tear. J Orthop Res. 2017 Nov;35(11):2499-2505. PMID: 28176368. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/28176368/
  • Sarver DC, Kharaz YA, Sugg KB, Gumucio JP, Comerford E, Mendias CL. Sex differences in tendon structure and function. J Orthop Res. 2017 Oct;35(10):2117-2126. PMID: 28071813. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/28071813/
  • Lee S, Gumucio J, Mendias C, Bedi A. What is the role of systemic conditions and options for manipulation of bone formation and bone resorption in rotator cuff tendon healing and repair? Tech Shoulder Elb Surg. 2017 Sep;18(3):113-120. PMID: 28966557. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/28966557/
  • Mendias CL. Fibroblasts take the centre stage in human skeletal muscle regeneration. J Physiol. 2017 Aug;595(15):5005. PMID: 28585689. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/28585689/
  • Oliver K, Awan T, Bayes M. Single- Versus Multiple-Site Harvesting Techniques for Bone Marrow Concentrate: Evaluation of Aspirate Quality and Pain. Orthop J Sports Med. 2017 Aug;5(8):2325967117724398. PMID: 28890905. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/28890905/
  • Saripalli AL, Sugg KB, Mendias CL, Brooks SV, Claflin DR. Active shortening protects against stretch-induced force deficits in human skeletal muscle. J Appl Physiol (1985). 2017 May;122(5):1218-1226. PMID: 28235860. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/28235860/
  • Sarver DC, Sugg KB, Disser NP, Enselman ERS, Awan TM, Mendias CL. Local cryotherapy minimally impacts the metabolome and transcriptome of human skeletal muscle. Sci Rep. 2017 May;7(1):2423. PMID: 28546635. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/28546635/
  • Dueweke JJ, Awan TM, Mendias CL. Regeneration of Skeletal Muscle After Eccentric Injury. J Sport Rehabil. 2017 Apr;26(2):171-179. PMID: 27992284. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/27992284/
  • Mendias CL, Schwartz AJ, Grekin JA, Gumucio JP, Sugg KB. Changes in muscle fiber contractility and extracellular matrix production during skeletal muscle hypertrophy. J Appl Physiol (1985). 2017 Mar;122(3):571-579. PMID: 27979985. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/27979985/
  • Sugg KB, Korn MA, Sarver DC, Markworth JF, Mendias CL. Inhibition of platelet-derived growth factor signaling prevents muscle fiber growth during skeletal muscle hypertrophy. FEBS Lett. 2017 Mar;591(5):801-809. PMID: 28129672. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/28129672/
  • Werner NL, Alghanem F, Rakestraw SL, Sarver DC, Nicely B, Pietroski RE, Lange P, Rudich SM, Mendias CL, Rojas-Pena A, Magee JC, Bartlett RH, Ozer K. Ex Situ Perfusion of Human Limb Allografts for 24 Hours. Transplantation. 2017 Mar;101(3):e68-e74. PMID: 28222055. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/28222055/
  • Gumucio JP, Flood MD, Bedi A, Kramer HF, Russell AJ, Mendias CL. Inhibition of prolyl 4-hydroxylase decreases muscle fibrosis following chronic rotator cuff tear. Bone Joint Res. 2017 Jan;6(1):57-65. PMID: 28108482. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/28108482/
  • Garcia SC, Dueweke JJ, Mendias CL. Optimal Joint Positions for Manual Isometric Muscle Testing. J Sport Rehabil. 2016 Nov;25(4):jsr.2015-0118. PMID: 27632883. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/27632883/
  • Griffin DR, Dickenson EJ, O'Donnell J, Agricola R, Awan T, Beck M, Clohisy JC, Dijkstra HP, Falvey E, Gimpel M, Hinman RS, Hölmich P, Kassarjian A, Martin HD, Martin R, Mather RC, Philippon MJ, Reiman MP, Takla A, Thorborg K, Walker S, Weir A, Bennell KL. The Warwick Agreement on femoroacetabular impingement syndrome (FAI syndrome): an international consensus statement. Br J Sports Med. 2016 Oct;50(19):1169-76. PMID: 27629403. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/27629403/
  • Wilde JM, Gumucio JP, Grekin JA, Sarver DC, Noah AC, Ruehlmann DG, Davis ME, Bedi A, Mendias CL. Inhibition of p38 mitogen-activated protein kinase signaling reduces fibrosis and lipid accumulation after rotator cuff repair. J Shoulder Elbow Surg. 2016 Sep;25(9):1501-8. PMID: 27068389. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/27068389/
  • Hudgens JL, Sugg KB, Grekin JA, Gumucio JP, Bedi A, Mendias CL. Platelet-Rich Plasma Activates Proinflammatory Signaling Pathways and Induces Oxidative Stress in Tendon Fibroblasts. Am J Sports Med. 2016 Aug;44(8):1931-40. PMID: 27400714. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/27400714/
  • Gumucio JP, Flood MD, Roche SM, Sugg KB, Momoh AO, Kosnik PE, Bedi A, Mendias CL. Stromal vascular stem cell treatment decreases muscle fibrosis following chronic rotator cuff tear. Int Orthop. 2016 Apr;40(4):759-64. PMID: 26224616. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/26224616/
  • Ozer K, Rojas-Pena A, Mendias CL, Bryner BS, Toomasian C, Bartlett RH. The Effect of Ex Situ Perfusion in a Swine Limb Vascularized Composite Tissue Allograft on Survival up to 24 Hours. J Hand Surg Am. 2016 Jan;41(1):3-12. PMID: 26710728. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/26710728/
  • Claflin DR, Roche SM, Gumucio JP, Mendias CL, Brooks SV. Assessment of the Contractile Properties of Permeabilized Skeletal Muscle Fibers. Methods Mol Biol. 2016;1460:321-36. PMID: 27492182. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/27492182/
  • Ozer K, Rojas-Pena A, Mendias CL, Bryner B, Toomasian C, Bartlett RH. Ex Situ Limb Perfusion System to Extend Vascularized Composite Tissue Allograft Survival in Swine. Transplantation. 2015 Oct;99(10):2095-101. PMID: 25929606. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/25929606/
  • Mendias CL, Bakhurin KI, Gumucio JP, Shallal-Ayzin MV, Davis CS, Faulkner JA. Haploinsufficiency of myostatin protects against aging-related declines in muscle function and enhances the longevity of mice. Aging Cell. 2015 Aug;14(4):704-6. PMID: 25808276. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/25808276/
  • Roche SM, Gumucio JP, Brooks SV, Mendias CL, Claflin DR. Measurement of Maximum Isometric Force Generated by Permeabilized Skeletal Muscle Fibers. J Vis Exp. 2015 Jun;(100):e52695. PMID: 26131687. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/26131687/
  • Russell KA, Ng R, Faulkner JA, Claflin DR, Mendias CL. Mouse forepaw lumbrical muscles are resistant to age-related declines in force production. Exp Gerontol. 2015 May;65:42-5. PMID: 25762422. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/25762422/
  • Gumucio JP, Sugg KB, Mendias CL. TGF-β superfamily signaling in muscle and tendon adaptation to resistance exercise. Exerc Sport Sci Rev. 2015 Apr;43(2):93-9. PMID: 25607281. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/25607281/
  • Mendias CL, Lynch EB, Gumucio JP, Flood MD, Rittman DS, Van Pelt DW, Roche SM, Davis CS. Changes in skeletal muscle and tendon structure and function following genetic inactivation of myostatin in rats. J Physiol. 2015 Apr;593(8):2037-52. PMID: 25640143. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/25640143/
  • Schwartz AJ, Sarver DC, Sugg KB, Dzierzawski JT, Gumucio JP, Mendias CL. p38 MAPK signaling in postnatal tendon growth and remodeling. PLoS One. 2015 Mar;10(3):e0120044. PMID: 25768932. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/25768932/
  • Davis ME, Korn MA, Gumucio JP, Harning JA, Saripalli AL, Bedi A, Mendias CL. Simvastatin reduces fibrosis and protects against muscle weakness after massive rotator cuff tear. J Shoulder Elbow Surg. 2015 Feb;24(2):280-7. PMID: 25213828. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/25213828/
  • Davis ME, Stafford PL, Jergenson MJ, Bedi A, Mendias CL. Muscle fibers are injured at the time of acute and chronic rotator cuff repair. Clin Orthop Relat Res. 2015 Jan;473(1):226-32. PMID: 25113269. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/25113269/
  • Fry CS, Lee JD, Mula J, Kirby TJ, Jackson JR, Liu F, Yang L, Mendias CL, Dupont-Versteegden EE, McCarthy JJ, Peterson CA. Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia. Nat Med. 2015 Jan;21(1):76-80. PMID: 25501907. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/25501907/
  • Mendias CL, Roche SM, Harning JA, Davis ME, Lynch EB, Sibilsky Enselman ER, Jacobson JA, Claflin DR, Calve S, Bedi A. Reduced muscle fiber force production and disrupted myofibril architecture in patients with chronic rotator cuff tears. J Shoulder Elbow Surg. 2015 Jan;24(1):111-9. PMID: 25193488. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/25193488/
  • Gumucio JP, Phan AC, Ruehlmann DG, Noah AC, Mendias CL. Synergist ablation induces rapid tendon growth through the synthesis of a neotendon matrix. J Appl Physiol (1985). 2014 Dec;117(11):1287-91. PMID: 25277742. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/25277742/
  • Jeffery N, Mendias C. Endocranial and masticatory muscle volumes in myostatin-deficient mice. R Soc Open Sci. 2014 Dec;1(4):140187. PMID: 26064569. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/26064569/
  • Oak NR, Gumucio JP, Flood MD, Saripalli AL, Davis ME, Harning JA, Lynch EB, Roche SM, Bedi A, Mendias CL. Inhibition of 5-LOX, COX-1, and COX-2 increases tendon healing and reduces muscle fibrosis and lipid accumulation after rotator cuff repair. Am J Sports Med. 2014 Dec;42(12):2860-8. PMID: 25245131. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/25245131/
  • Gumucio J, Flood M, Harning J, Phan A, Roche S, Lynch E, Bedi A, Mendias C. T lymphocytes are not required for the development of fatty degeneration after rotator cuff tear. Bone Joint Res. 2014 Sep;3(9):262-72. PMID: 25185444. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/25185444/
  • Wood LK, Kayupov E, Gumucio JP, Mendias CL, Claflin DR, Brooks SV. Intrinsic stiffness of extracellular matrix increases with age in skeletal muscles of mice. J Appl Physiol (1985). 2014 Aug;117(4):363-9. PMID: 24994884. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/24994884/
  • Sugg KB, Lubardic J, Gumucio JP, Mendias CL. Changes in macrophage phenotype and induction of epithelial-to-mesenchymal transition genes following acute Achilles tenotomy and repair. J Orthop Res. 2014 Jul;32(7):944-51. PMID: 24700411. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/24700411/
  • Gumucio JP, Korn MA, Saripalli AL, Flood MD, Phan AC, Roche SM, Lynch EB, Claflin DR, Bedi A, Mendias CL. Aging-associated exacerbation in fatty degeneration and infiltration after rotator cuff tear. J Shoulder Elbow Surg. 2014 Jan;23(1):99-108. PMID: 23790676. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/23790676/
  • Bedi A, Lynch EB, Sibilsky Enselman ER, Davis ME, Dewolf PD, Makki TA, Kelly BT, Larson CM, Henning PT, Mendias CL. Elevation in circulating biomarkers of cartilage damage and inflammation in athletes with femoroacetabular impingement. Am J Sports Med. 2013 Nov;41(11):2585-90. PMID: 23959964. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/23959964/
  • Davis ME, Gumucio JP, Sugg KB, Bedi A, Mendias CL. MMP inhibition as a potential method to augment the healing of skeletal muscle and tendon extracellular matrix. J Appl Physiol (1985). 2013 Sep;115(6):884-91. PMID: 23640595. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/23640595/
  • Gumucio JP, Flood MD, Phan AC, Brooks SV, Mendias CL. Targeted inhibition of TGF-β results in an initial improvement but long-term deficit in force production after contraction-induced skeletal muscle injury. J Appl Physiol (1985). 2013 Aug;115(4):539-45. PMID: 23766498. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/23766498/
  • Mendias CL, Lynch EB, Davis ME, Sibilsky Enselman ER, Harning JA, Dewolf PD, Makki TA, Bedi A. Changes in circulating biomarkers of muscle atrophy, inflammation, and cartilage turnover in patients undergoing anterior cruciate ligament reconstruction and rehabilitation. Am J Sports Med. 2013 Aug;41(8):1819-26. PMID: 23739685. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/23739685/
  • Weist MR, Wellington MS, Bermudez JE, Kostrominova TY, Mendias CL, Arruda EM, Larkin LM. TGF-β1 enhances contractility in engineered skeletal muscle. J Tissue Eng Regen Med. 2013 Jul;7(7):562-71. PMID: 22371337. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/22371337/
  • Gumucio JP, Mendias CL. Atrogin-1, MuRF-1, and sarcopenia. Endocrine. 2013 Feb;43(1):12-21. PMID: 22815045. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/22815045/
  • Gumucio JP, Davis ME, Bradley JR, Stafford PL, Schiffman CJ, Lynch EB, Claflin DR, Bedi A, Mendias CL. Rotator cuff tear reduces muscle fiber specific force production and induces macrophage accumulation and autophagy. J Orthop Res. 2012 Dec;30(12):1963-70. PMID: 22696414. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/22696414/
  • Davis ME, Stafford PL, Bradley JR, Bedi A, Mendias CL. Improvement in the Contractility and Muscle Stem Cell Density of the Rotator Cuff Following Surgical Repair: A Case Report. JBJS Case Connect. 2012 Oct;2(4):e75. PMID: 29252371. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/29252371/
  • Calve S, Isaac J, Gumucio JP, Mendias CL. Hyaluronic acid, HAS1, and HAS2 are significantly upregulated during muscle hypertrophy. Am J Physiol Cell Physiol. 2012 Sep;303(5):C577-88. PMID: 22785117. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/22785117/
  • Mendias CL, Gumucio JP, Lynch EB. Mechanical loading and TGF-β change the expression of multiple miRNAs in tendon fibroblasts. J Appl Physiol (1985). 2012 Jul;113(1):56-62. PMID: 22539168. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/22539168/
  • Mendias CL, Gumucio JP, Bakhurin KI, Lynch EB, Brooks SV. Physiological loading of tendons induces scleraxis expression in epitenon fibroblasts. J Orthop Res. 2012 Apr;30(4):606-12. PMID: 21913219. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/21913219/
  • Mendias CL, Gumucio JP, Davis ME, Bromley CW, Davis CS, Brooks SV. Transforming growth factor-beta induces skeletal muscle atrophy and fibrosis through the induction of atrogin-1 and scleraxis. Muscle Nerve. 2012 Jan;45(1):55-9. PMID: 22190307. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/22190307/
  • Mendias CL, Kayupov E, Bradley JR, Brooks SV, Claflin DR. Decreased specific force and power production of muscle fibers from myostatin-deficient mice are associated with a suppression of protein degradation. J Appl Physiol (1985). 2011 Jul;111(1):185-91. PMID: 21565991. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/21565991/
  • Faulkner JA, Davis CS, Mendias CL, Brooks SV. The aging of elite male athletes: age-related changes in performance and skeletal muscle structure and function. Clin J Sport Med. 2008 Nov;18(6):501-7. PMID: 19001883. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/19001883/
  • Mendias CL, Bakhurin KI, Faulkner JA. Tendons of myostatin-deficient mice are small, brittle, and hypocellular. Proc Natl Acad Sci U S A. 2008 Jan;105(1):388-93. PMID: 18162552. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/18162552/
  • Mendias CL, Marcin JE, Calerdon DR, Faulkner JA. Contractile properties of EDL and soleus muscles of myostatin-deficient mice. J Appl Physiol (1985). 2006 Sep;101(3):898-905. PMID: 16709649. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/16709649/
  • Mendias CL, Tatsumi R, Allen RE. Role of cyclooxygenase-1 and -2 in satellite cell proliferation, differentiation, and fusion. Muscle Nerve. 2004 Oct;30(4):497-500. PMID: 15372441. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/15372441/