5-alpha Reductase
Understanding Post-Finasteride Syndrome: Causes, Symptoms, and Treatment Approaches
Post-finasteride syndrome (PFS) is a poorly understood but increasingly recognized condition characterized by persistent physical, neurological, and sexual symptoms that continue long after discontinuing finasteride. Finasteride is a 5-alpha reductase inhibitor commonly prescribed for androgenic alopecia and benign prostatic hyperplasia. Although effective in reducing dihydrotestosterone (DHT) levels, its systemic effects can disrupt hormonal and neurosteroid balance, resulting in long-term adverse outcomes in a subset of users.